Advanced B Complex

Purchase Advanced B Complex

Advanced B Complex (AGE Amadori).

The core of Advanced B Complex is two unique B vitamins: the world’s first pharmaceutical-grade‡ Pyridoxamine, a form of vitamin B6 (not the common pyridoxine form), and Benfotiamine, an extremely well absorbed and utilized form of vitamin B1. These nutrients are Amadorins, powerful “late-phase” inhibitors of the formation of Advanced Glycation Endproducts (AGEs).

In the body, AGEs form when the structure of bodily proteins is warped by exposure to blood sugar, leading to crosslinking, stiffening, and loss of function. Also includes a complete, balanced spectrum of B vitamins, including the newly-discovered redox-cofactor nutrient pyrroloquinoline quinone (PQQ), essential for the activity of the lysine-metabolizing enzyme AS-dehydrogenase.

Size: 90 Vegi-Caps
Weight: 315 mg
Code:
100% VEGETARIAN

SUPPLEMENT FACTS:
Serving Size: 1 Capsule
Pyridoxamine (a form of vitamin B6) ...... 33 mg
Thiamin (as Benfotiamine 40 mg) ... 28 mg
B2 (Riboflavin) ...... 0.5 mg
B3 (Niacin (as 24 mg Inositol Hexanicotinate)) . 19 mg
B5 (d-Ca Pantothenate) ..... 17 mg
B12 (Cyanocobalamin) ...... 4 mcg
Folic Acid ..... 50 mcg
Biotin .......... 50 mcg
Pyrroloquinoline quinone (PQQ) ... 5 mcg
Choline (Bitartrate) ..... 44 mg
Inositol (from Inositol, Inositol Hexanicotinate) .. 166 mg

*Dietary Reference Intake not established.
Other ingredients: May contain microcrystalline cellulose and silicon dioxide. Capsule: vegetarian (hydroxypropylmethylcellulose, gellan gum, water and potassium acetate).

‡ True pharmaceutical grade. Pyridoxamine supplements previously released by other companies have been found to contain 5-15% of an unknown contaminant, revealed on HPLC but not standard semi qualitative assays endorsed by the United States Pharmacopoeia (USP).

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use
Take one capsules three times daily, or as directed by a qualified health consultant.

Main Applications
* Aging
* AGE Inhibitor
* Brain Support
* B Vitamin Deficiency
* Diabetic Neuropathy
* Diabetic Complications

Source
Multi-Sourced

Pregnancy / Nursing
None.

Cautions
At extremely high doses, vitamin B6 has been found to cause nerve damage. The Institute of Medicine has established a no adverse effects level (NOAEL) of 200 mg of Vitamin B6 per day, and a safe upper limit (UL) of 100mg per day. Do not exceed these limits from all vitamin B6 supplements (pyridoxine and Pyridoxamine) combined. Discontinue vitamin B6 supplementation and consult a physician immediately if you experience neurological symptoms such as numbness, burning, pain, pricking, or tingling in your fingers or feet, or unusual clumsiness.

Persons taking many drugs - including 5-fluorouracil, hydralazine, levodopa, nortriptyline, phenytoin, and tetracycline- should not take high dose vitamin B6 supplements.

We all get old; it is the only justice in this world, or so the saying goes. Yet that may change as our understanding of the aging process keeps improving. There are two well-established mechanisms of slow cellular degeneration that reveal the aging process and lead to the degeneration of our tissues. One of those is the generation of free radicals. Free radicals are atoms with an unpaired electron. They react with cells extracting the missing electron. This causes cellular damage and leaves the cell permanently injured.

There is another process that leaves cells warpped and wounded: glycation reactions. These reactions hinder the function and damage the structure of proteins, and have been linked to many progressive diseases of aging. Advanced glycation end-products (AGEs) form when the structure of the proteins found in our body is damaged by the exposure to sugars. Glycation is a major source of tissue dysfunction in the elderly and is one of the major consequences of sustained hyperglycemia. AGE formation occurs in everyone and the process can lead to harmful inflammatory and autoimmune conditions. Glycated proteins have been found in the collagen of connective tissue, in arterial collagen, in kidney glomerular basement membrane, in the lens of the eye, in nerve myelin proteins and in the low-density lipoprotein circulating in the blood. The list of pathologies where glycation plays a role is extensive and includes vascular disease, erectile dysfunction, kidney disease, joint stiffness, loss of skin elasticity, arthritis, cataracts, retinopathy, neuropathy, Alzheimer's Dementia, impaired wound healing, urinary incontinence, complications of diabetes, and cardiomyopathies.


How does Advanced B Complex work?

Advanced B Complex has been formulated to prevent the glycation of proteins. The basis behind Advanced B Complex lies on two exceptional B vitamins: the world’s first pharmaceutical-grade Pyridoxamine, a form of vitamin B6, and Benfotiamine, a particularly bioavailable form of vitamin B1. Both nutrients are Amadorins because they prevent the formation of AGEs. Pyridoxamine inhibits AGE formation by hindering the degradation of Amadori intermediates, by scavenging toxic glucose byproducts and by trapping reactive oxygen species. Supplementation with high doses of benfotiamine can prevent metabolic damage associated with glycation by diverting excess metabolites toward the pentose pathway. Furthermore, benfotiamine can inhibit the three biochemical pathways involved in the pathogenesis of hyperglycemia. Advanced B Complex contains a wide spectrum of B vitamins, choline and inositol.


Research

The non-enzymatic glycation of proteins was first discovered with Hemoglobin A1c. This molecule is still used for the long-term management of diabetics. The formation of glycated proteins is a significant source of damage to the proteome and genome and is thought to play a central part in the development of diabetic complications and atherosclerosis. Hyperglycemic conditions such as diabetes accelerate the formation of modified proteins because increased levels of glucose in the blood accelerate the formation of AGE’s.

Pyridoxamine is an Amadorin; a post-Amadori AGE inhibitor. It prevents the conversion of protein Amadori intermediates to protein AGE’s. The vitamin can inhibit post Amodori steps of the Maillard reaction (the non-enzymatic reaction of sugars with amino acids) by sequestering catalytic metal ions and preventing the oxidative degradation of Amadori intermediates. Pyridoxamine prevents the formation of diabetic complications in animal models. In vitro, the molecule prevented the degradation of protein glycation intermediates, which would inhibit the chemical modification of tissue proteins.

Benfotiamine is a lipid soluble derivative of thiamine, with much better bioavailability, and it also interferes with the formation of AGE. In vitro experiments on human cells showed that the presence of benfotiamine in a high glucose environment reduced AGE formation to levels similar to the ones expected at normal blood glucose levels. It also allows normal cellular growth, a process normally impeded by the presence of high amounts of glucose. Benfotiamine’s value is related to its ability at inhibiting the three major pathways implicated in the pathogenesis of hyperglycemia. Benfotiamine stimulates transketolase activity and diverts excess metabolites towards the pentose pathway. In animals, the vitamin prevented diabetic retinopathy. An important finding for the treatment and prevention of complications associated with diabetes.

The health benefits associated with AGE inhibitors are significant. Advanced B Complex prevents the formation of glycated proteins. The synergistic combination of ingredients found in Advanced B Complex makes it a promising candidate for the treatment of diabetes and other conditions where oxidative reactions and carbonyl compounds convey pathogenicity. If you suffer from hyperglycemia, this supplement is a must; it is the most advanced supplement available for the prevention of glucose-mediated damage. If you do not suffer from elevated glucose levels, Advanced B Complex will lend you a hand for years to come, adverting tissue damage caused by AGE formation and accumulation.

References

P Ulrich, X Zhang. "Pharmacological reversal of advanced glycation end-product-mediated protein crosslinking," Diabetologia. 40: S157-S159 (1997).

M F Usta, M Kendirci, T J Bivalacqua, S Gur, W J G Hellstrom, N A Foxwell, S Cellek. "Delayed Administration of ALT-711, but not of Aminoguanidine, Improves Erectile Function in Streptozotocin Diabetic Rats: Curative Versus Preventive Medicine," 11th World Congress of the International Society for Sexual and Impotence Research, Buenos Aires (October 2004).

G Perry, M A Smith. "Active Glycation in Neurofibrillary pathology of Alzheimer's Disease: N-(Carboxymethyl) Lysine and Hexitol-Lysine", Free Radical Biology & Medicine Vol. 31 (2), pp. 175-180, (2001).

Forbes JM, et.al. "The breakdown of pre-existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes," The FASEB Journal express article 10.1096/fj.02-1102fje. (Published online: July 18, 2003)

Khalifah RG, Baynes JW, Hudson BG. Amadorins: novel post-Amadori inhibitors of advanced glycation reactions. Biochem Biophys Res Commun. 1999 Apr 13;257(2):251-8.

Voziyan PA, Hudson BG. Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage. Cell Mol Life Sci. 2005 Aug;62(15):1671-81.

Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003 Mar;9(3):294-9. Epub 2003 Feb 18.

Pomero F, Molinar Min A, La Selva M, Allione A, Molinatti GM, Porta M. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta Diabetol. 2001;38(3):135-8.

Obrenovich ME, Monnier VM. Vitamin B1 blocks damage caused by hyperglycemia. Sci Aging Knowledge Environ. 2003 Mar 12;2003(10):PE6.

Khalifah RG, Baynes JW, Hudson BG. Amadorins: novel post-Amadori inhibitors of advanced glycation reactions. Biochem Biophys Res Commun. 1999 Apr 13;257(2):251-8. Review.

Voziyan PA, Hudson BG. Pyridoxamine: the many virtues of a maillard reaction inhibitor. Ann N Y Acad Sci. 2005 Jun;1043:807-16.

Voziyan PA, Metz TO, Baynes JW, Hudson BG. A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation. J Biol Chem. 2002 Feb 1;277(5):3397-403. Epub 2001 Nov 29.

Voziyan PA, Hudson BG. Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage. Cell Mol Life Sci. 2005 Aug;62(15):1671-81. Review

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