Certificates of Analysis and Articles
July 3, 2008
Certificates of Analysis
Relentless Improvement brand products are offered with third party Certificates of Analysis derived from expensive, time-consuming, finished product testing. Only a small handful of companies worldwide provide this degree of product quality assurance and public disclosure.
No laws or regulations require us to document the quality of our products, we choose to do business this way so that you may have the ultimate level of confidence in our supplements.
FDA registered, USA based analytical testing laboratories are used for all of our product testing. Manufacturer's Certificates of Analysis, unfortunately, are not always reliable and frequently lack key quality assurance controls and information.
Our public CoA's tie back to the exact product we are shipping to you, and usually note the finished product lot number. They are properly dated, signed, and publicly identified with our address information and testing laboratory information for that specific product.
Relentless Improvement brand documented products are your key to safety and efficacy and meet/exceed all FDA, WHO and California Prop 65 standards for claimed label content, sterility and freedom from heavy metal contaminants.
Consider and understand these facts: A molecule does not know in which country it was manufactured. Any country is capable of manufacturing high and low quality materials. Furthermore, a high quality raw material might acquire a contaminant in the encapsulation/bottling process.
So don't ask where the raw material was manufactured. It doesn't matter. What does matter is the quality of the bottled finished product.
Click on the product name below to view the CoA in PDF format for what is currently shipping to you.
Acetyl-L-Carnosine Eye Drops Pharmaceutical grade, full potency, documented sterile.
Alpha-GPC (Choline Alfoscerate) New batch in progress.
Aniracetam (60 count) Pharmaceutical grade, superior purity and potency.
Centrophenoxine (Meclofenoxate) Pharmaceutical purity, exceeds all standards, metals well under limits.
EgCG Green Tea SuperPotent Extract True pharmaceutical grade, ultra-pure, free of residual solvents.
Galantamine Pharmaceutical purity, exceeds all standards, metals well under limits.
Idebenone Pharmaceutical grade. Our product is stronger potency than the reference standard.
Iodine/Iodide High Potency Complex Our Iodine/Iodide product testing is performed by an FDA registered analytical laboratory. The metals content per serving is documented at 1/3rd to 1/10th or less of CA Prop 65 "No Significant Risk" levels.
Relentless Improvement is not required to adhere to Prop 65 due to our size, but we test as if we were for the peace of mind of our customers. Proposition 65 was passed nearly 10 years ago by the voters in California and established California-only allowable levels of daily ingestion of four heavy metals:
- Material : Allowable Level
- Arsenic: 10 micrograms (our product less than 0.50 mcg/undetectable)
- Cadmium: 4.1 micrograms (our product less than 0.50 mcg/undetectable)
- Lead: 15 micrograms (our product less than 0.50 mcg/undetectable)
- Mercury: In development, but for now 0.3 micrograms (our product less than 0.15 mcg/undetectable)
Relentless Improvement Iodine/Iodide supplement exceeds in every measure the most conservative guidelines of Califormia Proposition 65 requirement. These are the most stringent of any state.
K2 menatetrenone Full 15 mg per capsule, plate count consistent with biofermentation derived material.
Lithium Orotate Purity exceeds all standards, plate count 28 times less than USDA allowable.
Oxiracetam Pharmaceutical purity exceeds all standards.
Phenibut Pharmaceutical purity.
Picamilon Reference standard was not available, total capsule mg referenced, plate count well under 100,000 allowed by World Health Organization quality control standards.
Piracetam Pharmaceutical purity.
Phenylpiracetam Verified via HPLC testing. Free of molds, yeasts, microbial.
Pramiracetam Pharmaceutical purity exceeds reference standard.
Pyritinol Pharmaceutical grade. Our product is stronger potency than the reference standard.
Resveratrol Ultra-pure, ultra-low emodin, resveratrol extract. New- now includes 6/23/2008 potency retest.
Strontium Citrate Pharmaceutical purity and exceeding all standards, metals well under limits.
Sulbutiamine A documented pharmaceutical grade.
Posted by Relentless Improvement on July 3, 2008 8:09 AM | Permalink
May 10, 2007
Ortho-Bone: "I thought you couldn't mix Calcium and Strontium?"
Q: What do you think about all these new supplements which contain a full day's dose of Strontium along with calcium, magnesium, and other key nutrients all in one convenient bottle?
A: They're a disaster.
In his review, Dr. Reginster specifically notes (pg. 1914) that "The simultaneous intake of [Strontium] and calcium remarkably reduces the bioavailability of [Strontium]. This is probably due to competition at the sites of active absorption. Simultaneous food intake also has a negative influence on the bioavailability of [Strontium]". Based on this critical factor, Dr. Reginster recommends that high-dose Strontium should not be taken "concomitantly with a meal or a calcium intake."
The competition between Strontium and calcium for absorption has long been known, and is the basis for the fact that all of the trials using strontium with major bone-health outcomes have carefully ensured that the supplement is taken on an empty stomach, away from calcium in food or in supplements. In the largest and best-designed trials women have taken their Strontium first thing in the morning, half an hour to an hour before breakfast, and/or three hours after dinner in the evening; they took their calcium supplements separately, with a meal.
This is the protocol supported by pharmacology and by clinical trials, and it is the one that we recommend unless your doctor specifies otherwise. It is obviously impossible to follow this protocol if you're taking a supplement that combines calcium and Strontium in the same pill or powder! Such formulations are, therefore, not the "convenient," "inexpensive" deals they initially seem, but are ill-designed and likely ineffective "kitchen sink" hodgepodges. Persons taking these supplements will not reap the full benefits of Strontium documented in the clinical trials. This is a major health issue, especially for people with advanced osteoporosis. If they and their physicians are taking these combination supplements instead of a reliable, separate supplement, or instead of an established drug therapy, the results could be ruinous.
Note that these problems do not hold if there is only a small, nutritional amount of Strontium in a core bone health supplement - doses in the range of 500 micrograms to 5 milligrams, which are typical of human dietary intakes. Such doses are appropriate, as they preserve the ratio of calcium and Strontium present naturally in whole-food diets. In fact, all natural calcium sources also have a small amount of Strontium in them, because of the similar metabolism of the two nutrients in living beings. The presence of calcium with no Strontium in calcium supplements might be expected to upset this natural balance, leading to suppression of whatever Strontium is in your diet, ultimately perturbing the natural balance of minerals in your bone.
Indeed, some evidence already exists that, over a lifetime, these low, nutritional doses of Strontium do have a role to play in your health. For example, it was discovered in the 1960s that areas with more Strontium in the water have a lower incidence of dental caries14,15 - a finding which was to be reinforced by the findings of at least eight more studies over the course of the next few decades.
Some of these Strontium-calcium combination products further shoot their users in the foot by using poor forms of key ingredients. Some, for instance, use poor forms of calcium, such as cheap calcium carbonate (which has low gastric tolerance and which reduces your absorption of other nutrients by neutralizing stomach acid) and synthetic calcium hydroxyapatite (an extremely poorly-absorbed synthetic calcium phosphate salt, not to be confused with ossein microcrystalline hydroxyapatite complex (MCHC), an extract of bone-health nutrients contained in an intact calcium crystalline matrix). Others use magnesium carbonate as a magnesium source; this is another antacid, and like calcium carbonate is poorly absorbed. Likewise, one of these products is even trading off of the research on Menatetrenone (MK-4) - the mammalian form of vitamin K2 and the one used in all of the "vitamin K2 menatetrenone" clinical trials - to sell another "vitamin K2:" the unproven, bacterial menaquinones.
Everyone concerned about their bone health needs a core calcium supplement such as Ortho-Bone Supplement, along with other key nutrients such as magnesium, vitamin D3, and Menatetrenone. In such a supplement, a small, nutritional dose of Strontium is a good balancing act, reflecting the trace levels of Strontium naturally present in food. But if you need the potent support of a megadose" "Strontium supplement, it should absolutely not come in a combination with calcium. You need a separate Strontium supplement, taken at a separate time.
This information is copyright the Editor of Advances magazine and may not be reproduced in whole or in part in any medium without the express permission of Advanced Orthomolecular Research. Used with permission.
Posted by Relentless Improvement on May 10, 2007 11:47 AM | Permalink
March 8, 2007
Osteoporosis Treatment By Traj Nibber
Please click this LINK to download and enjoy a great article by Traj Nibber of Advanced Orthomolecular Research on using supplements to support osteoporosis sufferers.
Loaded with the latest research.
Posted by Relentless Improvement on March 8, 2007 11:33 AM | Permalink
December 21, 2005
Persistance of Cognitive Enhancement. Nefiracetam, Tacrine (galantamine) and Deprenyl
Very interesting results in this article from the American College of Neuropsychopharmacology.
They were testing the persistance of cognition enhancement obtained from the use of nefiracetam, deprenyl (for neuroprotection) and tacrine (similar in action to Galantamine).
Partial abstract:
"Recent data suggest that Alzheimer's patients who discontinue treatment with cholinesterase inhibitors have a significantly delayed cognitive decline as compared to patients receiving placebo. Such observations suggest cholinesterase inhibitors to provide a disease-modifying effect as well as symptomatic relief and, moreover, that this benefit remains after drug withdrawal. Consistent with this suggestion, we now demonstrate that chronic administration of tacrine, nefiracetam, and deprenyl, drugs that augment cholinergic function, increases the basal frequency of dentate polysialylated neurons in a manner similar to the enhanced neuroplasticity achieved through complex environment rearing."
Bottom-line except from the article:
"Our observations are consistent with the idea that a chronic drug regimen or a complex environment induces a more robust memory pathway that can acquire and consolidate new information more efficiently. This hypothesis finds support in the improved learning behavior and enhanced resistance to cholinergic deficits seen following either intervention. Furthermore, the level of enhancement of basal neuroplastic status achieved by either drug or environmental intervention correlates directly with improved spatial learning ability. "
You can read the full article by clicking here. 188kb PDF
Posted by Relentless Improvement on December 21, 2005 4:31 PM | Permalink
Does Vitamin E Kill?
Learn the truth about Vitamin E by clicking here (2.75mb PDF download). Enjoy this write-up from Advanced Orthomolecular Research (www.aor.ca).
Posted by Relentless Improvement on December 21, 2005 11:59 AM | Permalink